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Technische Universitaet Darmstadt

OFFER DESCRIPTION 12 PhD positions within the MSCA Doctoral Network “SYNSENSO”: Cell-free synthetic biology for combinatorial biosensor design The Doctoral Network SYNSENSO Cell-free synthetic biology for combinatorial biosensor design, funded within the framework of the Marie Skłodowska-Curie Actions (MSCA), follows an interdisciplinary and cross-sectoral approach by bringing together academic and industrial experts from the fields of cell-free synthetic biology and molecular sensor design to develop novel combinatorial biosensors. Five academic research groups and two industrial partners, coordinated by Technische Universität Darmstadt in Germany, join forces in SYNSENSO to create a mobility and training platform for young scientists by means of cross-site, interdisciplinary research projects. The PhD students will work on individual research projects in order to devise new logic circuits in cell-free systems, build novel responsive elements for analyte detection and integrate logic circuits with response elements to build and test next-generation, combinatorial biosensors. The specific research projects at the different groups are listed below. In addition to the host institutes (see below), the consortium also includes associated academic and industrial partners (Imperial College London (UK), Nuclera Nucleics Ltd. (UK), BioMerieux SA (France), LenioBio GmbH (Germany), BRAIN Biotech AG (Germany), Advance Biotech (Spain)), which are available for secondments and collaborations. Candidate profile: MSc, MRes, MEng, or equivalent in Life Science (Biology, Biochemistry, Biophysics, etc), Bioengineering, Physics or a related discipline Wet-lab experience, in particular with genetic engineering or molecular biology – Interested to work in the field of synthetic biology Appreciation for interdisciplinary work and proactive drive to collaborate across disciplines proficient in English language Enrolment, eligibility, salary: Applicants must have obtained their masters degree and must not have a doctoral degree at the date of their recruitment – Applicants should not have been living in the country of the host institution for which they are applying for more than 12 months in the last 3 years (exception: refugee status). Applicants can be of any nationality. Subject to the successful signing of the EU Grant Agreement, SYNSENSO is planned to start with and the start of the individual doctoral project should be between and The successful candidate will receive a financial package including mobility and family allowance (if applicable), and will be employed according to the rules for Early Stage Researchers in an Marie Skłodowska-Curie Actions Doctoral Network (DN) and the general regulations of each host institution. The MSCA-DN will cover 3 years of full-time research. Final contract length and extension options depend on the host institution. Application: Applications should include a motivation letter, CV, copy of transcripts and of obtained degree and contact details of 2 references. Applicants should provide a ranked list of projects they are most interested to work on. – Please send your application via email: Application deadline: Doctoral Projects: DC1 – Cell-free RNA-based logic circuits, Host: Prof. Heinz Koeppl, Technische Universität Darmstadt, Germany DC2 – Machine-learning based design and optimization of analyte-responsive ribozymes, Host: Prof. Beatrix Suess, Technische Universität Darmstadt, Germany DC3 – CRISPR-based RNA editing tools for cell-free biosensors, Host: Prof. Tom de Greef, Eindhoven University of Technology, Netherlands DC4 -Modeling and simulation of cell-free synthetic circuits, Host: Prof. Tom de Greef, Eindhoven University of Technology, Netherlands DC5 – Enhanced cell-free lysates with pre-expressed regulators, Host: Prof. Heinz Koeppl, Technische Universität Darmstadt, Germany DC6 – Cell-free responsive elements and biosensors for DNA repair enzymes, Host: Prof. Francesco Ricci, Tor Vergata Universita degli Studi di Roma, Italy DC7 – RNA-binding proteins for circuit design and detection of viral infection, Host: Dr. Velia Siciliano, Istituto Italiano di Technologia, Naples, Italy DC8 – DNA/RNA responsive elements for cell-free biosensors, Host: Prof. Francesco Ricci, Tor Vergata Universita degli Studi di Roma, Italy DC9 – Cell-free synthesis of RNA aptamers on a biochip, Host: Dr. Ralf Strasser, Dynamic Biosensors GmbH, Munich, Germany (PhD awarded from TU Darmstadt) DC10 – Cell-free responsive elements for antibodies and proteins detection, Host: Dr. Bruna Marini, Ulisse Biomed GmbH, Udine, Italy (PhD awarded from Tor Vergata Universita degli Studi di Roma) DC11 – Intein-based logic gates for multiplexed designs, Host: Prof. Karen Polizzi, Imperial College London, UK (will be funded through the UKRI Horizon Europe Guarantee Funding Scheme) DC12 – Developing phosphorylation cascades in cell-free circuits, Host: Prof. Karen Polizzi, Imperial College London, UK (will be funded through the UKRI Horizon Europe Guarantee Funding Scheme

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