PhD Biology – synthetic cell composites, Immunotherapy (m/f/d)

The INM – Leibniz Institute for New Materials in Saarbrücken, Germany, is an internationally leading center for materials research, with a particular focus on biomaterials and biointerfaces, and their exploitation for medical applications. We are seeking PhD students with a background in biology, biochemistry, biophysics, chemistry or physics to join our “Immuno-Materials” group and work on the development of advanced synthetic cell systems for applications at the intersection of cancer immunotherapy and immunoregulatory materials. INM’s research group Immuno-Materialsinvestigates how microscale cell-like materials can be formed such that they combine multiple life-like functionalities and can be integrated into living systems. For this we apply organoid cultures, bottom-up synthetic biology and microfluidics to reconstitute immunoregulatory processes for therapeutic applications. In our new projects Synthetic Tumor Immune Microenvironments and Synthetic Lymphatic Tissues we invite applications for three PHD STUDENTS (F/M/D) on development of new synthetic cell composites for immunotherapy positions starting on November 1 st 2023 (with some flexibility). Design and characterize synthetic cell models with immunological properties. Investigate immunoregulatory interactions between synthetic cells, cancer cells and immune cells. Develop new strategies to culture tumor organoids for immunotherapeutic purposes. Investigate the activation of primary human immune cells by synthetic cell materials. You will work on scientifically interesting and technically relevant challenges in a motivated research group that collaborates with leading researchers and institutions. in an institute that supports you to perform high-quality research and to present and publish your research results. in an interdisciplinary and international institute with excellent infrastructure. at the heart of the Greater Region (Germany, France, Luxemburg, Belgium) Master’s degree in biology, biochemistry, biophysics, chemistry, physics, or a related field. Interest and possibly experience in biohybrids,synthetic biology or organoid culture. Previous experience with cell culture, advanced light microscopy imaging, electron microscopy or transcriptome profiling is beneficial. Very good communication and writing skills and thorough command of the English language. German language skills are beneficial but no required a comprehensive benefits package (flexible working hours, mobile working, company pension scheme) with a 3-year contract based on TV-L E% remuneration with the possibility to increase based on transparent performance criteria